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34000-39-0

34000-39-0 structure
34000-39-0 structure
  • Name: Homobutein
  • Chemical Name: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
  • CAS Number: 34000-39-0
  • Molecular Formula: C16H14O5
  • Molecular Weight: 286.27900
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2017-05-31 11:19:17
  • Modify Date: 2026-08-15 20:43:38
  • Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].
Name (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
Synonyms 4,2',4'-Trihydroxy-3-methoxychalcone
Einecs -7
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)
homobitein
3-O-Methylbutein
(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
2',4,4'-trihydroxy-3-methoxychalcone
4,2',4'-trihydroxy-3-methoxy-trans-chalcone
4,2',4'-Trihydroxy-3-methoxy-trans-chalkon
HOMOBUTEIN
1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)
EINECS 251-782-7
HOMOBUTEIN hplc
2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE
(E)-2',4,4'-trihydroxy-3-methoxychalcone
2',4,4'-trihydroxy-3-dimethoxychalcone
3-O-methylbutein
3-METHOXY-2',4',4-TRIHYDROXYCHALCONE
(E)-1-(2，4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one
Acrylophenone,2',4'-dihydroxy-3-(p-hydroxy-m-methoxyphenyl)
Description Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].
Related Catalog
In Vitro Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1]. Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1]. Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2]. Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3]. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 20, 24, 28, 32, 40 μM Incubation Time: 2 h Result: Showed inhibition of viability in K562 cells. Cell Viability Assay[2] Cell Line: Toxoplasma gondii RH-2F strain Concentration: 1 μg/mL Incubation Time: 72 h Result: Surpressed 19.48% of the Toxoplasma gondii.
References

[1]. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

[2]. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383.

[3]. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32.

[4]. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.
Density 1.369 g/cm3
Boiling Point 523.8ºC at 760 mmHg
Melting Point 207-212ºC
Molecular Formula C16H14O5
Molecular Weight 286.27900
Flash Point 197.6ºC
Exact Mass 286.08400
PSA 86.99000
LogP 2.70810
Index of Refraction 1.684
HS Code 2914509090
HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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