Name | (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one |
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Synonyms |
2',4,4'-trihydroxy-3-methoxychalcone
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl) 3-O-Methylbutein 1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one EINECS 251-782-7 2',4,4'-trihydroxy-3-dimethoxychalcone 4,2',4'-trihydroxy-3-methoxy-trans-chalcone Acrylophenone,2',4'-dihydroxy-3-(p-hydroxy-m-methoxyphenyl) 4,2',4'-Trihydroxy-3-methoxy-trans-chalkon Homobutein |
Description | Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4]. |
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Related Catalog | |
In Vitro | Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1]. Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1]. Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2]. Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3]. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 20, 24, 28, 32, 40 μM Incubation Time: 2 h Result: Showed inhibition of viability in K562 cells. Cell Viability Assay[2] Cell Line: Toxoplasma gondii RH-2F strain Concentration: 1 μg/mL Incubation Time: 72 h Result: Surpressed 19.48% of the Toxoplasma gondii. |
References |
Density | 1.369 g/cm3 |
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Boiling Point | 523.8ºC at 760 mmHg |
Melting Point | 207-212ºC |
Molecular Formula | C16H14O5 |
Molecular Weight | 286.27900 |
Flash Point | 197.6ºC |
Exact Mass | 286.08400 |
PSA | 86.99000 |
LogP | 2.70810 |
Index of Refraction | 1.684 |
HS Code | 2914509090 |
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Precursor 6 | |
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DownStream 1 | |
HS Code | 2914509090 |
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Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |