2126803-41-4
2126803-41-4 structure
- Name: RIP2 Kinase Inhibitor 4
- Chemical Name: RIP2 Kinase Inhibitor 4
- CAS Number: 2126803-41-4
- Molecular Formula: C50H66F2N14O7S
- Molecular Weight: 1045.21
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2021-12-23 12:08:33
- Modify Date: 2024-01-11 13:43:47
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RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].
| Name | RIP2 Kinase Inhibitor 4 |
|---|
| Description | RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1]. |
|---|---|
| Related Catalog | |
| Target |
cIAP1 RIPK2:8 (pIC50) |
| In Vitro | RIP2 Kinase Inhibitor 4 (Compound 20) utilizes a novel inhibitor of apoptosis (IAP) binder. RIP2 Kinase Inhibitor 4 possess comparatively reduced binding potency at both cIAP1 and XIAP BIR3 domains and increased potency at the XIAP BIR2 domain[1]. RIP2 Kinase Inhibitor 4 (Compound 20) recruits the IAP E3 ligases and shows markedly reduced inhibition of muramyl dipeptide (MDP)-stimulated TNFα production in human peripheral blood mononuclear cells (PBMCs) (pIC50 of 9.3)[1]. |
| In Vivo | The initial in vivo assessment of RIP2 Kinase Inhibitor 4 (Compound 20) in rats dosed at 0.5 mg/kg SC demonstrated high levels of RIPK2 degradation and inhibition of MDP-stimulated TNFα release at the final 48 h time point[1]. |
| References |
| Molecular Formula | C50H66F2N14O7S |
|---|---|
| Molecular Weight | 1045.21 |