1263132-08-6
1263132-08-6 structure
- Name: MRT-81
- Chemical Name: MRT-81
- CAS Number: 1263132-08-6
- Molecular Formula: C31H29N3O5S
- Molecular Weight: 555.64
- Catalog: Signaling Pathways Stem Cell/Wnt Smo
- Create Date: 2022-02-21 19:51:18
- Modify Date: 2026-08-26 10:11:02
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MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1].
| Name | MRT-81 |
|---|---|
| Synonyms |
N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-cboxamide
[1,1'-Biphenyl]-4-cboxamide, N-[2-methyl-5-[[thioxo[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]phenyl] Smo,Smoothened,human,C3H10T1/2 cells,inhibit,Shh-light2 cells,rodent,BODIPY-cyclopamine,MRT81,MRT-81,rat anule cell precursors,Inhibitor,MRT 81 MRT-81, 10 mM in DMSO MRT-81 ，E0480 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]cbamothioyl]benzamide |
| Description | MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 41 nM (Shh-light2 cells Smo receptors)[1] |
| In Vitro | MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1]. MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1]. MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM, 2 h, 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1]. |
| References |
| Molecular Formula | C31H29N3O5S |
|---|---|
| Molecular Weight | 555.64 |