1233332-37-0
1233332-37-0 structure
- Name: Ex26
- Chemical Name: Ex 26
- CAS Number: 1233332-37-0
- Molecular Formula: C28H28ClFN2O3
- Molecular Weight: 494.98
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2022-03-28 19:14:59
- Modify Date: 2024-01-20 20:35:24
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Ex26 (S1P1-IN-Ex26) is a potent and selective Sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].
| Name | Ex 26 |
|---|---|
| Synonyms |
MFCD30537540
1-{[(5'-{[1-(4-Chloro-3-methylphenyl)ethyl]amino}-2'-fluoro-3,5-dimethyl-4-biphenylyl)carbonyl]amino}cyclopropanecarboxylic acid Cyclopropanecarboxylic acid, 1-[[[5'-[[1-(4-chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]- Ex26 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid 1-[[[5′-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2′-fluoro-3,5-dimethyl[1,1′-biphenyl]-4-yl]carbonyl]amino]cyclopropanecarboxylic acid |
| Description | Ex26 (S1P1-IN-Ex26) is a potent and selective Sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1]. |
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| Related Catalog | |
| Target |
IC50: 0.93 nM (S1P1)[1] |
| In Vitro | Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1]. Cell Viability Assay[1] Cell Line: U2OS cells, and Chinese hamster ovary cells Concentration: 0-10 μM Incubation Time: 1 hour Result: Confirmed a potent and selective antagonist of S1P1 (IC50=0.93 nM). |
| In Vivo | Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress[1]. Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1]. Animal Model: Eight-week-old male C57Bl/6J mice[1] Dosage: 3 mg/kg Administration: Intraperitoneal injection; 3 mg/kg; once daily; 3 days Result: Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen. Animal Model: Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg; once daily; 15 days Result: Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.3±55.0 °C at 760 mmHg |
| Molecular Formula | C28H28ClFN2O3 |
| Molecular Weight | 494.98 |
| Flash Point | 337.4±31.5 °C |
| Exact Mass | 494.177246 |
| LogP | 6.12 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.639 |