910045-32-8

910045-32-8 structure

Name: PQ 69
Chemical Name: PQ 69
CAS Number: 910045-32-8
Molecular Formula: C₂₀H₁₉FN₄O
Molecular Weight: 350.39
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2022-03-28 00:03:20
Modify Date: 2024-01-29 10:03:53
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1].

Name	PQ 69
Synonyms	3H-Pyrazolo[4,3-c]quinolin-3-one, 4-(butylamino)-2-(3-fluorophenyl)-1,2-dihydro- MFCD30182281 4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

Description	PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
References	[1]. Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10(4):619-29.