1637677-22-5

1637677-22-5 structure

Name: Povorcitinib
Chemical Name: Povorcitinib
CAS Number: 1637677-22-5
Molecular Formula: C₂₃H₂₂F₅N₇O
Molecular Weight: 507.46
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-03-23 13:58:25
Modify Date: 2026-07-15 22:54:30
Povorcitinib is a potent and selective inhibitor of JAK1. Povorcitinib has the potential for the research of disease selected from cutaneous lupus erythematosus (CLE) and Lichen planus (LP) (extracted from patent WO2021076124A1)[1].

Name	Povorcitinib
Synonyms	(S)-4-(3-(cyanomethyl)-3-(3',5'-dimethyl-1H,1'H-[4,4'-bipyrazol]-1-yl)azetidin-1-yl)-2,5-difluoro-N-(1,1,1-trifluoropropan-2-yl)benzamide 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-pyrazolyl]-1-azetidinyl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide

Description	Povorcitinib is a potent and selective inhibitor of JAK1. Povorcitinib has the potential for the research of disease selected from cutaneous lupus erythematosus (CLE) and Lichen planus (LP) (extracted from patent WO2021076124A1)[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1[1]
References	[1]. Paul Smith, et al. Use of jak1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (lp). Patent WO2021076124A1.

Molecular Formula	C₂₃H₂₂F₅N₇O
Molecular Weight	507.46