2749554-00-3
2749554-00-3 structure
- Name: DX2-201
- Chemical Name: DX2-201
- CAS Number: 2749554-00-3
- Molecular Formula: C18H28N2O6S2
- Molecular Weight: 432.55
- Create Date: 2022-05-19 06:04:50
- Modify Date: 2024-01-13 12:42:49
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DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects[1].
| Name | DX2-201 |
|---|
| Description | DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects[1]. |
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| Related Catalog | |
| Target |
IC50: 312 nM (OXPHOS complex I)[1] |
| In Vitro | DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS[1]. DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium[1]. DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC50 = 312 nM)[1]. DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively[1]. |
| References |
| Molecular Formula | C18H28N2O6S2 |
|---|---|
| Molecular Weight | 432.55 |