1272719-00-2

1272719-00-2 structure

Name: KX-826
Chemical Name: Benzamide, 4-[3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-
CAS Number: 1272719-00-2
Molecular Formula: C₂₁H₁₅F₅N₄O₂S
Molecular Weight: 482.43
Catalog: Research Areas Cancer
Create Date: 2022-07-02 18:35:24
Modify Date: 2024-01-10 20:27:41
Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research[1].

Name	Benzamide, 4-[3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-
Synonyms	KX-826

Description	Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> Others >> Androgen Receptor
In Vitro	Androgen receptor antagonist 2 (example 12) inhibits PSA production with an IC50 of 0.28 μM in LNCaP cells[1]. Androgen receptor antagonist 2 (2.5 μM, 48 h) inhibits prostate cancer cells viability[1]. Cell Viability Assay[1] Cell Line: LNCaP and 22RV1 cells Concentration: 2.5 μM Incubation Time: 48 h Result: Inhibited cell viability with inhibition rates of 86% and 61% for LNCaP and 22RV1 cells, respectively.
In Vivo	Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice[1]. Animal Model: Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g[1] Dosage: 0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse) Administration: Topical application, twice daily for 4 weeks Result: Stimulated hair growth in dose dependent patterns.
References	[1]. Youzhi Tong. Androgen receptor antagonists and uses thereof. WO2011029392A1.