| Description |
Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research[1].
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| Related Catalog |
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| In Vitro |
Androgen receptor antagonist 2 (example 12) inhibits PSA production with an IC50 of 0.28 μM in LNCaP cells[1]. Androgen receptor antagonist 2 (2.5 μM, 48 h) inhibits prostate cancer cells viability[1]. Cell Viability Assay[1] Cell Line: LNCaP and 22RV1 cells Concentration: 2.5 μM Incubation Time: 48 h Result: Inhibited cell viability with inhibition rates of 86% and 61% for LNCaP and 22RV1 cells, respectively.
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| In Vivo |
Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice[1]. Animal Model: Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g[1] Dosage: 0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse) Administration: Topical application, twice daily for 4 weeks Result: Stimulated hair growth in dose dependent patterns.
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| References |
[1]. Youzhi Tong. Androgen receptor antagonists and uses thereof. WO2011029392A1.
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