2566522-50-5

2566522-50-5 structure

Name: Antifungal agent 25
Chemical Name: Antifungal agent 25
CAS Number: 2566522-50-5
Molecular Formula: C₂₀H₁₄ClFN₄OS
Molecular Weight: 412.87
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2022-06-30 17:34:28
Modify Date: 2025-08-21 10:45:50
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].

Name	Antifungal agent 25

Description	Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Antifungal agent 25 (compound A31) shows antifungal effect with MIC values of <0.03, <0.03, <0.03, 0.25, 0.5 µg/mL for Candida albicans (SC5314), Candida albicans ((GIM 2.194), Cryptococcus neoformans (GIM 2.209), Candida tropicalis (GIM 2.183), Aspergillus fumigatus (cgmcc 3.7795), respectively[1]. Antifungal agent 25 shows moderate antifungal activity with MIC values of 0.5, >64 µg/mL for strain CaR (fluconazole-resistant strain of Candida albicans) and strain 17# (fluconazole and itraconazole resistant strain of Candida albicans), respectively[1]. Antifungal agent 25 (0.015 mg/mL) blocks the biosynthesis of ergosterol by inhibiting the key enzyme lanosterol 14a-demethylase (CYP51)[1]. Antifungal agent 25 shows less likely to produce drug-drug interactions with IC50s of 4.47, 2.87, 1.04, 31.3, 10.1 µM for α-naphthoflavone (CYP1A2), sulfaphenazole (CYP2C9), ticlopidine (CYP2C19), quinidine (CYP2D6), and ketoconazole (CYP3A4), respectively[1].
In Vivo	Antifungal agent 25 (2 mg/kg; i.v.) exhibits stable metabolic property in SD rats[1]. Pharmacokinetic Parameters of Antifungal agent 25 in SD rats[1]. dose(mg/kg) C0(ng/mL) T1/2(h) Vdss(L/kg) Cl (mL/min/kg) AUC0-last (ng·h/mL) AUC0-inf (ng·h/mL) 2 mg/kg 482±108 3.34±2.37 10.3±3.12 69.4±18.8 483±137 5.5±136SD rats; 2 mg/kg; i.v.[1]. Animal Model: SD rats[1] Dosage: 2 mg/kg Administration: I.v. Result: Exhibited stable metabolic property in SD rats.
References	[1]. Zhao L, et al. Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. Eur J Med Chem. 2022; 228:113987.

Molecular Formula	C₂₀H₁₄ClFN₄OS
Molecular Weight	412.87

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2566522-50-5	332849-40-8
1809167-48-3	2077083-94-2
2566522-60-7	2640054-39-1
1265166-14-0	2710259-38-2
2572713-30-3	2639531-53-4
903468-72-4	903200-10-2
903469-05-6	903192-38-1
883467-08-1	883470-59-5
895843-59-1	903467-90-3
901886-43-9	368840-65-7