Name | ASK1-IN-3 |
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Description | ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1]. |
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Related Catalog | |
Target |
IC50: 33.8 nM (ASK1)[1] |
In Vitro | ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1]. ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1]. Apoptosis Analysis Cell Line: HepG2[1] Concentration: 10, 20 and 50 μM Incubation Time: 48 hours Result: Induced PARP cleavage in a dose dependent manner. Cell Cycle Analysis Cell Line: HepG2[1] Concentration: 1, 2, 4, 8, and 16 μM Incubation Time: 24 hours Result: Significantly arrested cycle progression at G1 phase. |
References |
Molecular Formula | C18H18N8O2 |
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Molecular Weight | 378.39 |