ASK1-IN-3
Modify Date: 2024-01-16 14:18:12
ASK1-IN-3 structure
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Common Name | ASK1-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 2426705-19-1 | Molecular Weight | 378.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18N8O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ASK1-IN-3ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1]. |
| Name | ASK1-IN-3 |
|---|
| Description | ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1]. |
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| Related Catalog | |
| Target |
IC50: 33.8 nM (ASK1)[1] |
| In Vitro | ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1]. ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1]. Apoptosis Analysis Cell Line: HepG2[1] Concentration: 10, 20 and 50 μM Incubation Time: 48 hours Result: Induced PARP cleavage in a dose dependent manner. Cell Cycle Analysis Cell Line: HepG2[1] Concentration: 1, 2, 4, 8, and 16 μM Incubation Time: 24 hours Result: Significantly arrested cycle progression at G1 phase. |
| References |
| Molecular Formula | C18H18N8O2 |
|---|---|
| Molecular Weight | 378.39 |