2417022-06-9

2417022-06-9 structure
2417022-06-9 structure
  • Name: MEK-IN-5
  • Chemical Name: MEK-IN-5
  • CAS Number: 2417022-06-9
  • Molecular Formula: C29H27FN4O10S2
  • Molecular Weight: 674.67
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2022-05-21 15:36:47
  • Modify Date: 2024-01-09 12:11:51
  • MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].

Name MEK-IN-5
Description MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].
Related Catalog
In Vitro MEK-IN-5 (compound 18h) shows anti-proliferation activities for different tumor cells and low toxicity for normal cells[1]. MEK-IN-5 (0.1, 1, 10 µM; 1, 2, 4, 6 h) decreases the expression level of pMEK and pERK in a dose-dependent and time-dependent manner[1]. MEK-IN-5 (1, 10 µM; 24 h) induces apoptosis in MDA-MB-231 cells[1]. MEK-IN-5 (100 µM; 2h) significantly induce NO release in HCT116 cells[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, HCT116, A549, Vero, HL7702 cells Concentration: Incubation Time: Result: Showed anti-proliferation activities in MDA-MB-231, HCT116, A549, Vero, HL7702 cells with IC50s of 0.034, 0.64, 1.35, 21.07, 5.62 µM, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 0.1, 1, 10 µM Incubation Time: 1, 2, 4, 6 h Result: Decreased the expression level of pMEK and pERK in a dose-dependent and time-dependent manner. Apoptosis Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 1, 10 µM Incubation Time: 24 h Result: Induced apoptosis in MDA-MB-231 cells.
References

[1]. Wang C, et al. Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs. Eur J Med Chem. 2020; 196:112271.

Molecular Formula C29H27FN4O10S2
Molecular Weight 674.67