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2754266-04-9

2754266-04-9 structure

2754266-04-9 structure

Name: TNIK-IN-4
Chemical Name: TNIK-IN-4
CAS Number: 2754266-04-9
Molecular Formula: C₂₀H₁₆FN₃O₃
Molecular Weight: 365.36
Catalog: Research Areas Cancer
Create Date: 2022-05-22 21:55:10
Modify Date: 2024-04-06 11:07:55
TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].

Name	TNIK-IN-4

Description	TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.61 μM (TNIK)[1]
In Vitro	TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM[1]. Cell Proliferation Assay Cell Line: HCT116 cells[1] Concentration: 0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM Incubation Time: 72 hours Result: Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM.
References	[1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.

Molecular Formula	C₂₀H₁₆FN₃O₃
Molecular Weight	365.36

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