TNIK-IN-4

Modify Date: 2025-09-10 12:31:17

TNIK-IN-4 structure	Common Name	TNIK-IN-4
	CAS Number	2754266-04-9	Molecular Weight	365.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₆FN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TNIK-IN-4

TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].

Name	TNIK-IN-4

Description	TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.61 μM (TNIK)[1]
In Vitro	TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM[1]. Cell Proliferation Assay Cell Line: HCT116 cells[1] Concentration: 0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM Incubation Time: 72 hours Result: Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM.
References	[1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.

Molecular Formula	C₂₀H₁₆FN₃O₃
Molecular Weight	365.36
InChIKey	RQFMJZLSYXPUQF-UHFFFAOYSA-N
SMILES	COc1cc(-c2ccc3c(c2)oc(=O)n3Cc2ccc(F)cc2)cnc1N

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