2756129-42-5

2756129-42-5 structure

Name: Tutuilamide A
Chemical Name: Tutuilamide A
CAS Number: 2756129-42-5
Molecular Formula: C₅₁H₆₉ClN₈O₁₂
Molecular Weight: 1021.59
Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
Create Date: 2022-05-22 16:13:23
Modify Date: 2026-07-16 17:49:38
Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].

Name	Tutuilamide A
Synonyms	(2S,3S)-N-((2S,5S,8S,11R,12S,15Z,18S,21R)-2-benzyl-15-ethylidene-21-hydroxy-5-((4-hydroxyphenyl)methyl)-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo(16.3.1)docosan-12-yl)-2-(((2S)-2-(((E)-4-chloro-3-methylbut-3-enoyl)amino)propanoyl)amino)-3-methylpentanamide (2S,3S)-N-((2S,5S,8S,11R,12S,18S,21R,Z)-2-benzyl-15-ethylidene-21-hydroxy-5-(4-hydroxybenzyl)-8-isopropyl-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-10-oxa-1,4,7,14,17-pentaazabicyclo(16.3.1)docosan-12-yl)-2-((S)-2-((E)-4-chloro-3-methylbut-3-enamido)propanamido)-3-methylpentanamide

Description	Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
Target	IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)[1]
References	[1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

Molecular Formula	C₅₁H₆₉ClN₈O₁₂
Molecular Weight	1021.59