1895049-73-6
1895049-73-6 structure
- Name: MT16-001
- Chemical Name: MT16-001
- CAS Number: 1895049-73-6
- Molecular Formula: C15H14N4Os
- Molecular Weight: 298.364
- Create Date: 2022-07-01 11:01:18
- Modify Date: 2024-02-12 18:46:10
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MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1.
| Name | MT16-001 |
|---|
| Description | MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1. |
|---|---|
| References | 1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943. |
| Molecular Formula | C15H14N4Os |
|---|---|
| Molecular Weight | 298.364 |