2279970-72-6
2279970-72-6 structure
- Name: Cl-OCH3
- Chemical Name: Cl-OCH3
- CAS Number: 2279970-72-6
- Molecular Formula: C24H19ClN2O2
- Molecular Weight: 402.878
- Create Date: 2022-07-10 19:31:53
- Modify Date: 2024-01-09 18:20:03
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Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively;Cl-OCH3 decreased expression of PD-L1 mRNA, promoter-dependent luciferase activity, and protein.In in vivo studies using a syngeneic mouse model bearing orthotopically injected 4T1 cells, Cl-OCH3 decreased tumor growth and weight and inhibited lung metastasis.Cl-OCH3 also decreased expression of CD3+/CD4+/CD25+/FoxP3+ regulatory T cells and increased the Teff/Treg ratio.
| Name | Cl-OCH3 |
|---|
| Description | Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively;Cl-OCH3 decreased expression of PD-L1 mRNA, promoter-dependent luciferase activity, and protein.In in vivo studies using a syngeneic mouse model bearing orthotopically injected 4T1 cells, Cl-OCH3 decreased tumor growth and weight and inhibited lung metastasis.Cl-OCH3 also decreased expression of CD3+/CD4+/CD25+/FoxP3+ regulatory T cells and increased the Teff/Treg ratio. |
|---|---|
| References | 1. Keshav Karki, et al. Cancer Res. 2020 Mar 1;80(5):1011-1023. |
| Molecular Formula | C24H19ClN2O2 |
|---|---|
| Molecular Weight | 402.878 |