307002-71-7

307002-71-7 structure

Name: CL-82198
Chemical Name: N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
CAS Number: 307002-71-7
Molecular Formula: C₁₇H₂₂N₂O₃
Molecular Weight: 302.37
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2016-07-02 17:36:43
Modify Date: 2024-01-08 22:12:27
CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.

Name	N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
Synonyms	IN1376 N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide CL-82198

Description	CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Cancer
References	[1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. [2]. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%