958588-17-5
958588-17-5 structure
- Name: Rv1625c agonist V-59
- Chemical Name: Rv1625c agonist V-59
- CAS Number: 958588-17-5
- Molecular Formula: C17H18FN7O2
- Molecular Weight: 371.376
- Create Date: 2022-07-27 16:43:25
- Modify Date: 2024-01-19 10:27:04
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Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium.
| Name | Rv1625c agonist V-59 |
|---|
| Description | Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium. |
|---|---|
| References | 1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862. |
| Molecular Formula | C17H18FN7O2 |
|---|---|
| Molecular Weight | 371.376 |