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  • DC Chemicals Limited
  • China
  • Product Name: GDC-0134
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1637394-01-4

1637394-01-4 structure
1637394-01-4 structure
  • Name: GDC-0134
  • Chemical Name: GDC-0134
  • CAS Number: 1637394-01-4
  • Molecular Formula: C19H20F4N6O2
  • Molecular Weight: 440.403
  • Create Date: 2022-09-11 11:50:53
  • Modify Date: 2024-04-10 00:51:55
  • GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).

Name GDC-0134
Description GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).
References 1. Jonathan S Katz, et al. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66.
Molecular Formula C19H20F4N6O2
Molecular Weight 440.403