GDC-0134
Modify Date: 2024-04-10 00:51:55
GDC-0134 structure
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Common Name | GDC-0134 | ||
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| CAS Number | 1637394-01-4 | Molecular Weight | 440.403 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20F4N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GDC-0134GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). |
| Name | GDC-0134 |
|---|
| Description | GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). |
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| References | 1. Jonathan S Katz, et al. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66. |
| Molecular Formula | C19H20F4N6O2 |
|---|---|
| Molecular Weight | 440.403 |