2375674-19-2
2375674-19-2 structure
- Name: PD-L1 inhibitor 4
- Chemical Name: PD-L1 inhibitor 4
- CAS Number: 2375674-19-2
- Molecular Formula: C50H48N6O10
- Molecular Weight: 892.966
- Create Date: 2022-07-13 08:59:44
- Modify Date: 2025-10-01 12:20:51
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PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay.
| Name | PD-L1 inhibitor 4 |
|---|
| Description | PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay. |
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| References | 1. Kawashita S, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2464-2467. |
| Molecular Formula | C50H48N6O10 |
|---|---|
| Molecular Weight | 892.966 |