2488745-53-3
2488745-53-3 structure
- Name: SIRT6 activator CL5D
- Chemical Name: SIRT6 activator CL5D
- CAS Number: 2488745-53-3
- Molecular Formula: C29H11Cl7N2O6
- Molecular Weight: 731.565
- Create Date: 2022-07-02 15:27:40
- Modify Date: 2024-04-03 15:23:10
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SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells.
| Name | SIRT6 activator CL5D |
|---|
| Description | SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells. |
|---|---|
| References | 1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399. |
| Molecular Formula | C29H11Cl7N2O6 |
|---|---|
| Molecular Weight | 731.565 |