1214468-35-5

1214468-35-5 structure

Name: SIRT6-IN-1
Chemical Name: 2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide
CAS Number: 1214468-35-5
Molecular Formula: C₁₉H₁₄N₄O₅S
Molecular Weight: 410.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2021-09-11 01:58:44
Modify Date: 2024-04-06 12:05:00
SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].

Name	2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide
Synonyms	2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]- MFCD11667663

Description	SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Metabolic Disease
Target	106 μM and 114 μM (SIRT6/SIRT2)[1]
References	[1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.