946347-36-0
946347-36-0 structure
- Name: UHRF1 PHD inhibitor MLD5
- Chemical Name: UHRF1 PHD inhibitor MLD5
- CAS Number: 946347-36-0
- Molecular Formula: C23H29N3O5S
- Molecular Weight: 459.561
- Create Date: 2022-07-16 09:46:01
- Modify Date: 2025-08-26 19:23:26
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UHRF1 PHD inhibitor MLD5 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=7.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD5 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
| Name | UHRF1 PHD inhibitor MLD5 |
|---|
| Description | UHRF1 PHD inhibitor MLD5 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=7.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD5 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells. |
|---|---|
| References | 1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10. |
| Molecular Formula | C23H29N3O5S |
|---|---|
| Molecular Weight | 459.561 |