922067-76-3
922067-76-3 structure
- Name: UHRF1 PHD inhibitor MLD4
- Chemical Name: UHRF1 PHD inhibitor MLD4
- CAS Number: 922067-76-3
- Molecular Formula: C22H32N4O4
- Molecular Weight: 416.522
- Create Date: 2022-07-01 14:17:27
- Modify Date: 2025-08-25 15:48:57
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UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
| Name | UHRF1 PHD inhibitor MLD4 |
|---|
| Description | UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells. |
|---|---|
| References | 1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10. |
| Molecular Formula | C22H32N4O4 |
|---|---|
| Molecular Weight | 416.522 |