2396718-52-6

2396718-52-6 structure

Name: AKT-IN-12
Chemical Name: AKT-IN-12
CAS Number: 2396718-52-6
Molecular Formula: C₄₂H₄₆N₂O₇S
Molecular Weight: 722.89
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-01 09:25:03
Modify Date: 2024-01-09 19:21:06
AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].

Name	AKT-IN-12

Description	AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	IC50: 0.55 μM (Akt)[1]
References	[1]. Yang J, et al. Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway. Eur J Med Chem. 2020;186:111898.

Molecular Formula	C₄₂H₄₆N₂O₇S
Molecular Weight	722.89