2411099-68-6

2411099-68-6 structure

Name: DPP-4/GPR119 modulator 1
Chemical Name: DPP-4/GPR119 modulator 1
CAS Number: 2411099-68-6
Molecular Formula: C₃₀H₃₉ClN₁₀O₃
Molecular Weight: 623.15
Catalog: Signaling Pathways GPCR/G Protein GPR119
Create Date: 2022-07-02 22:23:04
Modify Date: 2024-01-11 22:13:09
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 µM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1].

Name	DPP-4/GPR119 modulator 1

Description	DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 µM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Signaling Pathways >> GPCR/G Protein >> GPR119 Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 4.9 µM (hERG)[1]
References	[1]. Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.

Molecular Formula	C₃₀H₃₉ClN₁₀O₃
Molecular Weight	623.15