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1043922-53-7

1043922-53-7 structure
1043922-53-7 structure
  • Name: Gü1303
  • Chemical Name: Gü1303
  • CAS Number: 1043922-53-7
  • Molecular Formula: C20H22N4O3
  • Molecular Weight: 366.41
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
  • Create Date: 2022-06-27 10:56:53
  • Modify Date: 2024-01-10 11:49:38
  • Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

Name Gü1303
Description Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Related Catalog
Target

Ki: 0.91 nM (mCatK)[1]

References

[1]. Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.

Molecular Formula C20H22N4O3
Molecular Weight 366.41
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