2414046-33-4

2414046-33-4 structure

Name: HDAC-IN-39
Chemical Name: HDAC-IN-39
CAS Number: 2414046-33-4
Molecular Formula: C₂₇H₂₆N₄O₄S
Molecular Weight: 502.58
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-29 12:52:51
Modify Date: 2024-01-08 09:07:30
HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells[1].

Name	HDAC-IN-39

Description	HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:1.07 μM (IC50) HDAC2:1.47 μM (IC50) HDAC3:2.27 μM (IC50) HDAC8:>10 μM (IC50)
References	[1]. Wu WC, et al. Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response. Eur J Med Chem. 2020 Apr 15;192:112158.

Molecular Formula	C₂₇H₂₆N₄O₄S
Molecular Weight	502.58