2414053-06-6

2414053-06-6 structure

Name: AChE/HDAC-IN-1
Chemical Name: AChE/HDAC-IN-1
CAS Number: 2414053-06-6
Molecular Formula: C₂₆H₂₇ClN₄O₃
Molecular Weight: 478.97
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-08-12 10:29:36
Modify Date: 2024-01-06 17:00:49
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1].

Name	AChE/HDAC-IN-1

Description	COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
Target	HDAC:0.23 nM (IC50)
In Vitro	COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively[1]. COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)[1]. COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity[1].
References	[1]. Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721.

Molecular Formula	C₂₆H₂₇ClN₄O₃
Molecular Weight	478.97