AChE/HDAC-IN-1
Modify Date: 2024-01-06 17:00:49
AChE/HDAC-IN-1 structure
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Common Name | AChE/HDAC-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2414053-06-6 | Molecular Weight | 478.97 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27ClN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE/HDAC-IN-1COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1]. |
| Name | AChE/HDAC-IN-1 |
|---|
| Description | COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1]. |
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| Related Catalog | |
| Target |
HDAC:0.23 nM (IC50) |
| In Vitro | COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively[1]. COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)[1]. COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity[1]. |
| References |
| Molecular Formula | C26H27ClN4O3 |
|---|---|
| Molecular Weight | 478.97 |