2482310-18-7
2482310-18-7 structure
- Name: Apoptotic agent-2
- Chemical Name: Apoptotic agent-2
- CAS Number: 2482310-18-7
- Molecular Formula: C25H16ClN7S
- Molecular Weight: 481.96
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-12 10:57:37
- Modify Date: 2024-01-11 21:12:50
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Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1].
| Name | Apoptotic agent-2 |
|---|
| Description | Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1]. |
|---|---|
| Related Catalog | |
| Target |
Bax Caspase 3 Bcl-2 |
| In Vitro | Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50 values of 1.96, 1.12, 2.38 and 107.5 µM, respectively[1]. Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1]. Cell Cycle Analysis[1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased. Apoptosis Analysis[1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%. |
| References |
| Molecular Formula | C25H16ClN7S |
|---|---|
| Molecular Weight | 481.96 |