Apoptotic agent-2
Modify Date: 2024-01-11 21:12:50
Apoptotic agent-2 structure
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Common Name | Apoptotic agent-2 | ||
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| CAS Number | 2482310-18-7 | Molecular Weight | 481.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H16ClN7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Apoptotic agent-2Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1]. |
| Name | Apoptotic agent-2 |
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| Description | Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1]. |
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| Related Catalog | |
| Target |
Bax Caspase 3 Bcl-2 |
| In Vitro | Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50 values of 1.96, 1.12, 2.38 and 107.5 µM, respectively[1]. Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1]. Cell Cycle Analysis[1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased. Apoptosis Analysis[1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%. |
| References |
| Molecular Formula | C25H16ClN7S |
|---|---|
| Molecular Weight | 481.96 |