101626-66-8
101626-66-8 structure
- Name: Dobutamine tartrate
- Chemical Name: Dobutamine tartrate
- CAS Number: 101626-66-8
- Molecular Formula: C22H29NO9
- Molecular Weight: 451.47
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2022-09-12 19:08:47
- Modify Date: 2024-01-08 19:10:49
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Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion[1][2][3][4].
| Name | Dobutamine tartrate |
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| Description | Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
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| Related Catalog | |
| In Vivo | Dobutamine tartrate has a rapid onset of action and a short half-life [2]. Dobutamine tartrate (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3]. Dobutamine tartrate results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3]. Low doses of Dobutamine tartrate significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3]. Dobutamine tartrate increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3]. Dobutamine tartrate increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4]. Animal Model: Tgαq*44 mice (heart failure models)[3] Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration: Intraperitoneal injection Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure. |
| References |
| Molecular Formula | C22H29NO9 |
|---|---|
| Molecular Weight | 451.47 |