2414598-85-7
2414598-85-7 structure
- Name: hCAIX-IN-12
- Chemical Name: hCAIX-IN-12
- CAS Number: 2414598-85-7
- Molecular Formula: C18H14N4O3S2
- Molecular Weight: 398.46
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-03 12:26:05
- Modify Date: 2024-01-09 12:22:22
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hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 µM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1].
| Name | hCAIX-IN-12 |
|---|
| Description | hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 µM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1]. |
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| Related Catalog | |
| Target |
IC50: 0.74 µM (CAIX); 10.78 µM (CAII)[1]. |
| In Vitro | hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC50s of 6.0 µM for HCT-116 cells[1]. hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions[1]. hCAIX-IN-12 (0-50 µM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells[1]. hCAIX-IN-12 (6.0 µM; 48 h) induces apoptosis in HCT-116 cells[1]. hCAIX-IN-12 (6.0 µM; 24,48 h) increases in the levels of ROS in HCT-116 cells[1]. hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase[1]. hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA[1]. |
| References |
| Molecular Formula | C18H14N4O3S2 |
|---|---|
| Molecular Weight | 398.46 |