RORγt inverse agonist 30

Modify Date: 2025-08-23 12:09:00

RORγt inverse agonist 30 structure	Common Name	RORγt inverse agonist 30
	CAS Number	1445901-41-6	Molecular Weight	441.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₁N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RORγt inverse agonist 30

RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].

Name	RORγt inverse agonist 30

Description	RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
Target	RORγt:46 nM (IC50)
In Vitro	RORγt inverse agonist 30 (compound 1) inhibits mouse Th17 cell differentiation with an IC50 of 0.67 μM[1].
In Vivo	RORγt inverse agonist 30 exhibits favorable pharmacokinetics profiles with T1/2 of 2.3 min, CLint of 612 μL/min/mg and CLint(liver) of 2423.5 mL/min/kg[1].
References	[1]. Nannan Sun, et al. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. Eur J Med Chem. 2020 Feb 1;187:111984.

Molecular Formula	C₂₄H₃₁N₃O₃S
Molecular Weight	441.59

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com