2643391-08-4
2643391-08-4 structure
- Name: TGR5 Receptor Agonist 3
- Chemical Name: TGR5 Receptor Agonist 3
- CAS Number: 2643391-08-4
- Molecular Formula: C29H27N3O6
- Molecular Weight: 513.54
- Catalog: Signaling Pathways GPCR/G Protein GPCR19
- Create Date: 2022-08-09 10:38:00
- Modify Date: 2024-01-03 02:19:11
-
TGR5 Receptor Agonist 3 (Compound 19) is a soft-drug G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist with reduced gallbladder-filling effects (favorable gallbladder safety), with EC50s of 16.4 and 209 nM for hTGR5 and mTGR5, respectively[1].
| Name | TGR5 Receptor Agonist 3 |
|---|
| Description | TGR5 Receptor Agonist 3 (Compound 19) is a soft-drug G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist with reduced gallbladder-filling effects (favorable gallbladder safety), with EC50s of 16.4 and 209 nM for hTGR5 and mTGR5, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TGR5 Receptor Agonist 3 (compound 19) (10-50μM, 2 hours) activates TGR5 in fetal rat intestinal cells (FRIC) and NCI-H716 cells to promote GLP-1 secretion in a dose-dependent manner[1]. |
| In Vivo | TGR5 Receptor Agonist 3 (compound 19) has good targeting and can effectively activate TGR5, thus promoting the secretion of GLP-1 in plasma and regulating the homeostasis of glucose metabolism in male ICR mice[1]. TGR5 Receptor Agonist 3 (compound 19) can be rapidly absorbed and metabolized in male ICR mice, and has a good safety profile[1]. TGR5 Receptor Agonist 3 (compound 19) (oral gavage; 50 mg/kg; one hour) can be gavaged into overnight-fasted male ICR mice for one hour with a Cmaxvalue of 0.003 μg/mL [1]. TGR5 Receptor Agonist 3 (compound 19) can reduce gallbladder-filling and safety in vivo[1]. |
| References |
| Molecular Formula | C29H27N3O6 |
|---|---|
| Molecular Weight | 513.54 |