2307699-34-7
2307699-34-7 structure
- Name: Thi-DPPY
- Chemical Name: Thi-DPPY
- CAS Number: 2307699-34-7
- Molecular Formula: C28H28ClN5O4S
- Molecular Weight: 566.07
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2022-08-17 07:01:27
- Modify Date: 2023-02-23 21:24:20
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Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1].
| Name | Thi-DPPY |
|---|
| Description | Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK3:1.38 nM (IC50) BTK:62.4 nM (IC50) |
| In Vitro | DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC50 of 39.0 µM[1]. |
| In Vivo | DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model[1]. DPPY (30, 60 mg/kg) significantly decreases the expression of IL-6, IL-17A, TNF-α and MDA in lung tissue in a dose dependent manner[1]. Animal Model: 5-6 week old, 20-25 g, C57BL mice (BLM-induced pulmonary inflammation and pulmonary fibrosis model)[1] Dosage: 30, 60 mg/kg Administration: I.g.; once daily for 14 days Result: Attenuated the pulmonary morphology changes and reduced the collagen disposition induced by BLM in mouse lung. |
| References |
| Molecular Formula | C28H28ClN5O4S |
|---|---|
| Molecular Weight | 566.07 |