1859978-72-5

1859978-72-5 structure

Name: WX-081
Chemical Name: WX-081
CAS Number: 1859978-72-5
Molecular Formula: C₃₄H₃₃ClN₂O₂
Molecular Weight: 537.09
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-18 08:46:20
Modify Date: 2024-01-04 12:34:54
WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for drug susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM[1].

Name	WX-081

Description	WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for drug susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Zhigang Huang, et al. Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. Bioorg Med Chem Lett. 2022 Sep 1;71:128824.

Molecular Formula	C₃₄H₃₃ClN₂O₂
Molecular Weight	537.09