- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Propargyl-PEG1-acid
- Price: Check
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Propargyl-PEG1-acid
- Price: ￥4126.0/1g ￥12106.0/5g
- Purity: 95.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Propargyl-PEG1-acid
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Propanoic acid, 3- (2-propynyloxy)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: Propargyl-PEG1-acid
- Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/25g
- Purity: 95.0%
- Stocking Period: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
55683-37-9
55683-37-9 structure
- Name: Propargyl-PEG1-acid
- Chemical Name: 3-prop-2-ynoxypropanoic acid
- CAS Number: 55683-37-9
- Molecular Formula: C6H8O3
- Molecular Weight: 128.12600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-10-29 06:12:30
- Modify Date: 2025-08-22 19:54:37
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Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].
| Name | 3-prop-2-ynoxypropanoic acid |
|---|---|
| Synonyms | Propargyl-PEG1-acid |
| Description | Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1]. |
| References |
| Density | 1.14g/cm3 |
|---|---|
| Boiling Point | 265.8ºC at 760 mmHg |
| Molecular Formula | C6H8O3 |
| Molecular Weight | 128.12600 |
| Flash Point | 113.9ºC |
| Exact Mass | 128.04700 |
| PSA | 46.53000 |
| LogP | 0.11090 |
| Index of Refraction | 1.463 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
|---|
