Propargyl-PEG1-acid

Modify Date: 2024-01-18 19:36:15

Propargyl-PEG1-acid structure	Common Name	Propargyl-PEG1-acid
	CAS Number	55683-37-9	Molecular Weight	128.12600
	Density	1.14g/cm3	Boiling Point	265.8ºC at 760 mmHg
	Molecular Formula	C₆H₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	113.9ºC

Use of Propargyl-PEG1-acid

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].

Name	3-prop-2-ynoxypropanoic acid
Synonym	More Synonyms

Description	Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].
References	[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

Density	1.14g/cm3
Boiling Point	265.8ºC at 760 mmHg
Molecular Formula	C₆H₈O₃
Molecular Weight	128.12600
Flash Point	113.9ºC
Exact Mass	128.04700
PSA	46.53000
LogP	0.11090
Index of Refraction	1.463
Storage condition	-20°C