2761578-18-9
2761578-18-9 structure
- Name: 20S Proteasome activator 1
- Chemical Name: 20S Proteasome activator 1
- CAS Number: 2761578-18-9
- Molecular Formula: C27H19ClF2N2OS
- Molecular Weight: 492.97
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2022-09-01 12:52:25
- Modify Date: 2024-02-14 16:43:01
-
20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1].
| Name | 20S Proteasome activator 1 |
|---|
| Description | 20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.3 μM (trypsin-like site), 0.7 μM (chymotrypsin-like site), 1.8 μM (caspase-like site)[1] |
| In Vitro | 20S Proteasome activator 1 (compound 19) (2.5-15 μM; 45 min) degrades 73% α-synuclein at 10 μM, and over 80% at 15 μM[1]. 20S Proteasome activator 1 (5-15 μM; 24 h) reduces 25% A53T mutant, and dose-dependently reduces enhancement of α-synuclein in Hek-293T cells (transiently transfected with an A53T mutant α-synuclein plasmid) at 5 μM; decreases 67% A53T α-synuclein at 15 μM[1]. |
| References |
| Molecular Formula | C27H19ClF2N2OS |
|---|---|
| Molecular Weight | 492.97 |