2416338-24-2
2416338-24-2 structure
- Name: Chitin synthase inhibitor 2
- Chemical Name: Chitin synthase inhibitor 2
- CAS Number: 2416338-24-2
- Molecular Formula: C20H19N3O3
- Molecular Weight: 349.38
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2022-09-12 07:46:42
- Modify Date: 2024-09-29 08:51:39
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Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].
| Name | Chitin synthase inhibitor 2 |
|---|
| Description | Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1]. |
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| Related Catalog | |
| Target |
IC50: 0.09 mM; Ki: 0.12 mM[1] |
| In Vitro | Chitin synthase inhibitor 2 (compound 2b) (0, 0.032, 0.126, and 0.25 mM) inhibits chitin synthase with inhibition constant Ki value of 0.12 mM and the inhibition percent (IP) of 78.3% at 0.3 mM[1]. Chitin synthase inhibitor 2 (1-4 μg/mL) has excellent antifungal activity with MIC (minimum inhibitory concentration) values of 2, 4, 1, and 2 μg/mL against C. albicans (ATCC 76615), A. fumigatus (GIMCC 3.19), C. albicans (ATCC 90023), and A. flavus (ATCC 16870), respectively[1]. Chitin synthase inhibitor 2 (128-512 g/mL) has no antibacterial activity against MRSA (N. 315), S. aureus (ATCC 25923), B. subtilis (ATCC 6633), C. coli (JM 109), P. aeruginosa (ATCC 9027), and B. proteus (ATCC 8427) [1]. |
| References |
| Molecular Formula | C20H19N3O3 |
|---|---|
| Molecular Weight | 349.38 |