1392421-71-4
1392421-71-4 structure
- Name: PI3K/mTOR Inhibitor-9
- Chemical Name: PI3K/mTOR Inhibitor-9
- CAS Number: 1392421-71-4
- Molecular Formula: C23H27N7O2
- Molecular Weight: 433.51
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2022-09-16 19:28:25
- Modify Date: 2024-01-12 20:10:38
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PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1].
| Name | PI3K/mTOR Inhibitor-9 |
|---|
| Description | PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1]. |
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| Related Catalog | |
| Target |
mTOR:38 nM (IC50, phospho-S6 cellular assay) PI3Kα:6.6 μM (IC50) PI3Kβ:>10 μM (IC50) PI3Kγ:6.6 μM (IC50) PI3Kδ:0.8 μM (IC50) mTOR:16 nM (IC50, Ser240/244 cellular assay) |
| In Vitro | PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ[1]. PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 µM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min)[1]. PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) [1]. |
| References |
| Molecular Formula | C23H27N7O2 |
|---|---|
| Molecular Weight | 433.51 |