179545-76-7
179545-76-7 structure
- Name: (Rac)-Tanomastat
- Chemical Name: (Rac)-Tanomastat
- CAS Number: 179545-76-7
- Molecular Formula: C23H19ClO3S
- Molecular Weight: 410.91
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2022-10-18 06:30:32
- Modify Date: 2024-01-10 12:02:55
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(Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].
| Name | (Rac)-Tanomastat |
|---|
| Description | (Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
MMP-2:11 nM (Ki) MMP-3:143 nM (Ki) MMP-9:301 nM (Ki) MMP-13:1470 nM (Ki) |
| In Vitro | Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2]. Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3]. |
| In Vivo | Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3]. Animal Model: Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)[3] Dosage: 100 mg/kg Administration: P.o.; daily for a 7-week period Result: Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively. |
| References |
| Molecular Formula | C23H19ClO3S |
|---|---|
| Molecular Weight | 410.91 |