260553-24-0

260553-24-0 structure

Name: RBP4 ligand-1
Chemical Name: RBP4 ligand-1
CAS Number: 260553-24-0
Molecular Formula: C₁₈H₁₈ClF₃N₄O₂
Molecular Weight: 414.81
Catalog: Research Areas Metabolic Disease
Create Date: 2022-09-08 12:11:58
Modify Date: 2025-10-01 21:40:28
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1].

Name	RBP4 ligand-1

Description	RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Retinol-Binding Protein 4 (RBP4) is a physiological carrier of retinol (vitamin A) in blood, delivering retinol from the liver to peripheral tissues.RBP4 ligand-1 has the ability to disrupt the RBP4–TTR protein–protein interaction (hRPB4–TTR). The RBP4–TTR FRET IC50 is 0.13±0.12 μM in FRET assay[1].
In Vivo	RBP4配体
References	[1]. Yingcai Wang, et al. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91.

Molecular Formula	C₁₈H₁₈ClF₃N₄O₂
Molecular Weight	414.81