260553-24-0

260553-24-0 structure
260553-24-0 structure
  • Name: RBP4 ligand-1
  • Chemical Name: RBP4 ligand-1
  • CAS Number: 260553-24-0
  • Molecular Formula: C18H18ClF3N4O2
  • Molecular Weight: 414.81
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2022-09-08 12:11:58
  • Modify Date: 2024-01-02 09:53:00
  • RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1].

Name RBP4 ligand-1
Description RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1].
Related Catalog
In Vitro Retinol-Binding Protein 4 (RBP4) is a physiological carrier of retinol (vitamin A) in blood, delivering retinol from the liver to peripheral tissues.RBP4 ligand-1 has the ability to disrupt the RBP4–TTR protein–protein interaction (hRPB4–TTR). The RBP4–TTR FRET IC50 is 0.13±0.12 μM in FRET assay[1].
In Vivo RBP4配体
References

[1]. Yingcai Wang, et al. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91.

Molecular Formula C18H18ClF3N4O2
Molecular Weight 414.81