1822355-27-0

1822355-27-0 structure

Name: SMO-IN-2
Chemical Name: SMO-IN-2
CAS Number: 1822355-27-0
Molecular Formula: C₂₅H₂₅F₄N₅O₂
Molecular Weight: 503.49
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2022-08-31 17:42:46
Modify Date: 2025-08-26 12:24:42
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

Name	SMO-IN-2

Description	SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
Target	IC50: 123.4 nM (Hh)[1]
In Vitro	SMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM[1].
References	[1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.

Molecular Formula	C₂₅H₂₅F₄N₅O₂
Molecular Weight	503.49