1415662-57-5

1415662-57-5 structure

Name: SphK1&2-IN-1
Chemical Name: 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)-
CAS Number: 1415662-57-5
Molecular Formula: C₁₄H₁₄N₂O₃S
Molecular Weight: 290.34
Catalog: Signaling Pathways Immunology/Inflammation SPHK
Create Date: 2022-11-12 15:41:50
Modify Date: 2024-01-12 10:35:45
SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

Name	2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)-

Description	SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> SPHK
Target	SphK1 SphK2
In Vitro	SphK1&2-IN-1 (化合物 40) (10 μM) 对 SphK1 和 SphK2 的抑制率分别为 14.3% 和 26.5%[1]。 SphK1&2-IN-1 (化合物 W4) (1-100 μM) 具有良好的热稳定性[1]。
References	[1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. [2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.